Geraniol-derived 1,2,4-trioxanes with potent in-vivo antimalarial activity.
نویسندگان
چکیده
Geraniol, an abundantly available naturally occurring allylic alcohol, has been used as a starting material to prepare a series of 6-[alpha-(3'-aryl-3'-hydroxypropyl)vinyl]-1,2,4-trioxanes. Some of these novel trioxanes have shown very promising antimalarial activity against multi-drug resistant Plasmodium yoelii in mice by both intramuscular (im) and oral routes.
منابع مشابه
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
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عنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 13 20 شماره
صفحات -
تاریخ انتشار 2003